Research and Clinical Studies
In addition to the general body of brain research, HAPPYneuron's scientific team in partnership with prestigious research institutions have studied the effectiveness of the exercises in a variety of conditions. Research has also shown our programs may be effective in improving cognitive symptoms related to a number of different conditions. Below is a sample list.
Studies related to:
Study
2016-2018: Translational Neuroscience Optimization of GlyT1 Inhibitor
Size
80 subjects
Research Institution
Yale University
Investigator
John H. Krystal, M.D.
Status
In Progress
Study
2016-2017: Exploring cognitive training as a non-pharmaceutical therapeutic intervention for people with Huntington's disease
Size
8 subjects
Research Institution
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Investigator
Emma Yhnell, Pr Anne Rosser
Status
In Progress
Study
2016-2017: Neural bases of intrinsic motivation for learning in individuals at clinical high risk (CHR) for psychosis
Size
12 subjects
Research Institution
Olin Neuropsychiatry Research Center, the Institute of Living at Hartford Hospital
Investigator
Jimmy Choi, Godfrey Pearlson, Michael Stevensn Joanna M. Fiszdon
Status
In Progress
Study
2016-2017: Cognitive training program on verbal memory in older women who are within a year of having undergone chemotherapy treatment for early‐stage breast cancer
Size
40 subjects
Research Institution
Rehabilitation Institute of Chicago, Northwestern Feinberg School of Medicine
Investigator
Leora R. Cherney, Diane F. Morean, Alyx Kesselring
Status
In Progress
Study
2016: CBT for psychosis in combination with Cognitive Remediation
Size
40 subjects
Research Institution
Addictions & Mental Health Services - Kingston Frontenac Lennox & Addington
Investigator
Dr. Farooq Naeem, Dr. Tariq Munshi, Dr. Muhammad Ayub, Dr. Rupy Johal
Status
In Progress
Study
2016: Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
Size
100 subjects
Research Institution
Bio functional Studies Institute - Universidad Complutense (Madrid)
Investigator
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
Status
In Progress
Study
2015-2018: Cognitive and Physical Training in Elderly: Behavioral and EEG study
Size
120 subjects
Research Institution
Laboratoire d'Etude des Mécanismes Cognitifs, Université Lumière Lyon 2, France
Investigator
Clémence Joubert (Ph.D student) & Hanna Chainay, Ph.D.
Status
In Progress
Study
2015-2017: Evaluation of Dallas Metrocare's Enhanced Program for Early Psychosis (ePEP)
Size
90 subjects
Research Institution
UT Southwestern Medical Center
Investigator
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
Status
In Progress
Study
2015-2016: Measuring the effectiveness of Cognitive Remediation on Schizophrenia and Depression
Research Institution
National Center of Neurology and Psychiatry, Japan
Investigator
Kazuyuki Nakagome, M.D., Ph.D.
Status
In Progress
Study
2014-2019: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
Size
75 subjects
Research Institution
University of British Columbia
Investigator
Todd Woodward, Ph.D.
Status
In Progress
Study
2014-2018: Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
Size
120 subjects
Research Institution
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Investigator
Dr Martin Lepage, Ashol K. Malla, Dr Philippe-Olivier Harvey, Dr. Christopher Bowie
Status
In Progress
Study
2014-2018: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
Size
75 subjects
Research Institution
University of British Columbia
Investigator
Todd Woodward, Mahesh Menon, Devon Andersen
Status
In Progress
Study
2014-2017: The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
Size
126 subjects
Research Institution
Psychiatric Center Copenhagen, Denmark
Investigator
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft.
Status
In Progress
Study
2014-2016: Cognitive Training protocols in people with Chronic Pain
Size
50 subjects
Research Institution
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Investigator
Dr. Melita Giummarra, Pr. Nellie Georgiou-Karistianis, Pr. Stephen Gibson, Katharine Baker
Status
In Progress
Study
2014-2016: Comparing interventions that have either been designed to target the positive symptoms (particularly delusions) or the cognitive symptoms (e.g., memory and language deficits) of Schizophrenia
Research Institution
School of Psychology, Flinders University, Adelaide, SA, Australia
Investigator
Dr Ryan Balzan
Status
In Progress
Study
2014-2015: Preparing people marginalized by mental health issues for further education/ employment through Education
Size
25 subjects
Research Institution
George Brown College
Investigator
Jaswant Kaur Bajwa, Alex Irwin
Status
In Progress
Study
2014: Increased activation in Broca's area after cognitive remediation in schizophrenia
Size
16 subjects
Research Institution
Lausanne Hospital, Switzerland
Investigator
Pascal Vianin, Ph.D., Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Status
Completed
Publication
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca's area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209. Click Here to Get an Electronic Copy
Study
2014: Remote Cognitive Remediation for Psychosis
Research Institution
Investigator
Status
In Progress
Study
2014: Cognitive Remediation for Geriatric Schizophrenia
Research Institution
Investigator
Status
In Progress
Study
2014: Short-term, Intensive Executive Functioning Training with an Active Placebo
Research Institution
Investigator
Status
In Progress
Study
2014: Remote Cognitive Remediation for Acutely Hospitalized Depression
Research Institution
Investigator
Status
In Progress
Study
2014: Cognitive training to improve language comprehension for seniors?
Size
50 subjects - under recruitment
Research Institution
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Investigator
Dr. Magdalene Ortmann, Prof. Dr. Harmut Meister, Prof. Dr. Josef Kessler, Prof. Dr. Thomas Kaul
Status
In Progress
Presentation
Study
2013-2016: Web-based cognitive training for breast cancer survivors
with cognitive complaints—a randomized controlled trial
Size
157 subjects
Research Institution
Unit for Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital and Department of Psychology and Behavioural Science, Aarhus University, Denmark
Investigator
MF Damholdt, M Mehlsen, MS O’Toole, RK Andreasen, AD Pedersen, R Zachariae.
Funded by
Research was supported by TrygFonden
Status
Completed
Publication
Study
2013-2015: Efficacy of psychological treatments for schizophrenia
Research Institution
School of Psychology, Flinders University, Adelaide, SA, Australia
Investigator
Dr Ryan Balzan
Status
In Progress
Study
2013-2015: Scanning Training Rehabilitation for Visual Field Loss after stroke at Home: The STaRFiSH Study
Research Institution
Glasgow Caledonian University
Investigator
Christine Hazelton, Dr. Alex Pollock
Status
In Progress
Study
2013-2015: Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia
Size
30 to 40 subjects
Research Institution
McGill University Psychiatry Department
Investigator
Philippe-Olivier Harvey
Status
In Progress
Study
2013-2014: Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study
Size
17 subjects
Research Institution
University of British Columbia
Investigator
Jennifer DiMauro
Status
Completed
Publication
Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.
Study
2012-2015: Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program
Size
190 subjects
Research Institution
Investigator
Julia Volkert, Supervisor: Prof. Dr. Andreas Reif
Status
In Progress
Study
2012: Conditions for Maximizing Effects of 90 Days of Brain Training
Size
350 subjects
Research Institution
Investigator
Status
Completed
Study
2011-2013: Neurocognitive Enhancement in a Vocational Services Program
Size
60 subjects
Research Institution
Investigator
Status
In Progress
Study
2011-2013: Cognitive Remediation for Treatment Resistant Depression
Research Institution
Investigator
Status
Completed
Publication
Bowie CR, Gupta M, Holshausen K, Jokic R, Best, M, Milev, R. Cognitive remediation for treatment resistant depression: Effects on cognition and functioning and the role of online homework. Journal of Nervous and Mental Disorders, 2013, 201, 680-685.
Study
2011: Increased employability of the unemployed aged 50+ through cognitive training?
Size
87 subjects
Research Institution
Investigator
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Status
Completed
Study
2010-2011: Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia
Size
30 subjects
Research Institution
Investigator
Funded by
NARSAD
Status
Completed
Presentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Publication
Bowie CR, McGurk SM, Mausbach BT, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real world behavior. American Journal of Psychiatry, 2012, 1-9
Study
2009-2011: Intensive Spatial Memory Training for older Adults
Size
40 subjects
Research Institution
Investigator
Status
Completed
Publication
Pending
Study
2009-2011: Neurocognitive Enhancement Therapy for Major Depressive Disorder
Size
40 subjects
Research Institution
Investigator
Status
Completed
Presentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Publication
Pending
Study
2009: Specificity and Generalizability of Cognitive Remediation and Functional Skills Training in Schizophrenia
Size
83 subjects
Research Institution
Investigator
Funded by
NARSAD
Status
Completed
Presentation
Cognitive Remediation in Psychiatry Conference, New York, June 2010
Publication
Pending
Study
2008-2012: Cognitive rehabilitation for depressed patients
Size
30 subjects
Research Institution
French National Science Research Center
Paris 6 University at La Pitié-Salpêtriére Hospital
Paris 6 University at La Pitié-Salpêtriére Hospital
Investigator
Diane Samama, Ouriel Grynszpan, Ph.D., Odile Komano, Fernando Perez Diaz, Julie Guertault, Franck Tarpin-Bernard, Ph.D., Pr. Roland Jouvent.
Status
Completed
Presentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Poster at Cognitive Remediation Conference 2012, New York, June 2012
Poster at Cognitive Remediation Conference 2012, New York, June 2012
Publication
Pending
Study
2008-2011: Cognitive remediation effectiveness for schizophrenic patients
Size
280 subjects multi-site
Investigator
Nicolas Franck, Institute for Cognitive Science, Lyon, France
Funded by
Funded by PHRC (French Government Funding Program for Clinical Research)
Status
Completed
Presentation
Poster at 9th World Congress of Biological Psychiatry, Paris, France, July 2009
Publication
Franck, N. et al. (2013). Specific vs general cognitive remediation for schizophrenia: a multicentre randomised trial. Schizophrenia Research, 147(1), pp. 68-74. Click Here to Get an Electronic Copy
Study
2008: Cognitive Training Improves Driving Skills
Size
90 subjects
Investigator
Status
Completed
Results
Subjects demonstrate an average of 14% improvement in key skills
Study
2008: Benefits of Online Cognitive Training
Size
217 subjects
Investigator
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Diana Miner, M.A., M.S., Gaël Allain, Ph.D.
Status
Completed
Results
Subjects demonstrate +8.5% average improvement
Publication
Pending
Study
2007: Alzheimer's patients maintain cognitive skills and improve self confidence
Size
47 subjects
Investigator
Dr. Foare, Sophia's Gardens, Alzheimer's disease clinic, Castelnau-le-Lez, France
Status
Completed
Study
2007: Online Cognitive Training Improves Cognitive Performance
Size
85 subjects
Investigator
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Gaël Allain, Ph.D.
Status
Completed
Results
85 HAPPYneuron Users show +16% average improvement in 18 weeks
Study
2007: Significant Brain Activity Improvement
Investigator
Robert Bender III, M.D., D.Michael
Funded by
The Center for Disease Control (CDC)
Status
Completed
Results
“Shows Significant Brain Activity Improvement. HAPPYneuron™ Games Key Component of Brain Wellness Program”
Study
2006-2008: Rehabilitation software program for schizophrenia patients
Size
28 subjects
Research Institution
Lausanne Hospital, Switzerland
Investigator
Funded by
CHUV (Centre Hospitalier Universitaire Vaudois)
Status
Completed
Publication
Vianin, P., Deppen, P., Croisile, B., Tarpin-Bernard, F., Sarrasin-Bruchez, P., Dukes, R., Grillon, M. Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. The Journal of Cognitive Rehabilitation, NeuroScience Publishers, Volume 28. Fall 2010, pp 11-21, Click Here to Get an Electronic Copy
Study
2006: Memory Stimulation. Which scientific benefits? Which exercises?
Size
39 subjects
Investigator
Status
Completed
Results
HAPPYneuron Users show +12% average improvement in 18 weeks
Publication
Study
2004-2006: MNESIS Project - Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies
Research Institution
Lyon 2 University, Lyon INSA (ICTT), Medica-France
Investigator
Michel C., Bobillier-Chaumon M.-E., Cohen-Montandreau V., Tarpin-Bernard F.
Funded by
French Ministry of Industry
Status
Completed
Presentation
Elderlies in residential home care units. Can ICT be considered as a social rebinding method? In Conférence EUTIC 2006
Publication
Marc-Eric Bobillier Chaumon, Christine Michel, Franck Tarpin Bernard & Bernard Croisile , Behaviour & Information Technology (2013): Can ICT improve the quality of life of elderly adults living in residential home care units? From actual impacts to hidden artefacts, Behaviour & Information Technology, pp 1-17. Click Here to Get an Electronic Copy
Study
2003-2006: The Importance of Memory and Concentration Skills for Schoolchildren
Size
130 subjects school children ages 10 and 11, over a 3 year time frame
Research Institution
City of Elancourt, France ; Association Initiatives Terrain, France ; Lille University, France
Investigator
Neukirch A., Fenouillet F., Hildebrandt R.
Status
Completed
Results
Better CMS score and various effects on recognition tasks.
Publication
Pending
Study
2001-2002: Transferability of Cognitive Training to every-day activities (AKA King 64)
Size
117 subjects children, 10 years old
Research Institution
EMC laboratory (Université Lyon II - CNRS), France
Investigator
Status
Completed
Results
Average of 40%+ improvements in various cognitive skills performance.
Publication